“ When dealing with the large capacity cases (220 Swift, 22-250, 22CM, 22XC), I can certainly understand the why someone would use heavier bullets (+75gr), but when using them for varmints, it seems like a person could easily run into a problem where either the bullets won't hold together, you're not pushing them fast enough to warrant the use of such a big case, or you're having to push a bullet that's so tough that it pencils through on impact. “
		
		
	 
	
		
	
	
		
		
			“…they are limiting themselves to 64gr-75gr bullets right off the bat “.
		
		
	 
	
		
	
	
		
		
			“…who buys a rifle with a custom barrel and only develops 2 or 3 loads for it? “
		
		
	 
Lefty - 
Howdy !  
None of the following is intended to sound coarse, harsh, abrupt; or smart _ _ _ at all;
and of course…. YRMV.
I have shot the .224” cal  Hornady 55SX  550+ fps above the Mv limit Hornady has suggested for that bullet.  The 55SX has a .009” thin jacket, and is a FB design with secant ogive; and an exposed lead nose on the core.
Using my “ .22-35 Remington “ wildcat as an example ( capacity 49.4gr H2O ), I had zero bullet blow ups on the way to the target. I was using a 24” SS  1-14  5-groove Hart, and retired the barrel when it started to keyhole bullets after reaching  3,400+ shot count. 
Within those 3,400+ shots, I encountered none of the ballistics mischief you mentioned in your first remark.   But hey, that’s just my experience. It’s a case capacity within the range of case’  “ capacities “ you noted.
Your ballistics topics and their contributing factors are multi-faceted.  Let’s talk about the idea of biasing bullet wt to the fore.  As regarding one potentially “ limiting “ themself to a certain weight span of bullets….It think it more likely one has a  specific  bullet already in mind that they want to try, and moreover… would really like to see group well; along w/ good terminal ballistics.  If  that  bullet disappoints, they  then  try another bullet.  Sure, they might give a variety of bullets a try over time; but one often starts out w/ a preferred bullet in mind.  The case size is selected based on what terminal ballistics ( and even terminal effects ) are desired when using the  chosen  bullet.  That is different thinking than… using a heavier bullet  because  the case has large capacity ( in that that calibre ) …. IMHO.
If one makes informed choices on bullet ( design, construction, weight ), and also on rifling twist and case size; there are not imposing  any “ limits “on themselves as regards  bullet choice with respect to weight. They will be shooting pretty much exactly what they want, certainly well within a bullet wt span of the size you mentioned. More to the point, IF there is some sort of bullet “ run off “ performed; the candidate bullets would probably be the  same  or very close to the same weight. ( IMHO ). With  this  approach, the “ limit “ is what range the shooter chooses to decline humane kills at, for example… a range at which one would be concerned about having a  “ crawler “ if considering taking a shot at 
groundhog.  “ Know when to say when “.
In response to your question:  
” …who buys a [ rifle with ] custom barrel and developers only 2 or 3 loads for it ? “.  
Well, I’ll give you  one  answer…..me.    When picking the bullet first, my intent is to use that one bullet / one load  ( on groundhog ) at all ranges out to the range “ limit “ mentioned above.   I myself use 450 ft lb as a guide for the minimum KE  I want to put on 
“ Soybeanus Digestus “ @ distance.  With the case capacity I mentioned and shooting an example 55SX bullet;  a  25” barrel along w/ proper powder / charge choices will easily give me a valid 500yd  anti-groundhog rifle;  as “ wind “ in NE Indiana isn’t  as large a consideration as it is out West.
Best of luck in your endeavors !
With regards,     
                    357Mag