I have both calibers. The 22-250 is a Savage LRPV with a 1:9 twist. The 22 Creedmoor is built on a Remington 700 action with a Proof Research barrel and has a 1:7.5 twist. I shoot up to 70 gr. bullets in the Savage and 80-85 gr. in the 22CM. I’m thinking of only keeping one and doing a re-barrel on the other. In equal weight bullets the speed difference is only about 100-150 fps with safe pressure loads. I shoot mainly paper and some steel and my range goes out to 300 yds. I shoot both as a single shot. Both are very accurate and I know or have heard about barrel life in the 22CM. So, which one would you keep and why?