No, it will not! I've been searching for the same application (AICS compatible mags in Rem 22-250) and these are the only things I have found - MDT (Modular Driven Technologies) makes a metal mag that sells for $79 each and Legacy Outdoors makes a polymer mag that sells for $59 each. I already have a couple of Legacy mags in .308 and I tried the 22-250 cartridge but it did NOT work consistently. I'll probably go with the MDT mags because the spring in the Legacy mags feel too weak to work reliably. Hope that helps.I found a Magpul 700 Hunter stock on clearance so I bought it. Anybody know if the 308 magazine will work with 22 250?