We in NW FL have some really big hogs that are no joke dangerous. All depend on if they are riled up or not. A 22 will kill an unaware hog, but a wounded or chased hog is one of the few animals that will turn to the attac and at 30 mph. A passing at full speed slash can upen you up, without you even felling it.
I prefer the lighter weight AR-15 in a 358 MGP with 200s but I also carry a 30x39 with 150s in a 308 barrel with a 1-10 twist.. The 358 MGP is a 6.8 SPC shortened .050 and necked up to 358 with a 40 degree shoulder. It is an absolute hammer loaded with 1680 at 2,500 fps.
I grew up in the Everglades moved to NW FL, the first hog I shot here in NW FL weighed 550 pounds. It is not a case of I think, I have been there done that, on the ground with handguns. The black bear hunters here hate the wild hogs here, because the hogs will kill their bear dogs in seconds, and the hogs even kill the hog hunters catch dogs. They are incredibly destructive on fields, looks like a B-52 flew over and dropped 500 pound bombs all over the field. I had a friend have a 30 acre feed corn field destroyed in one night by hogs, had to put a dozer on it to plant it again. You never want wild hogs on your property.
I would not carry my 300 BO to any hog hunt here. They are a quiet cartridge designed for guards not a DG cartridge and never will be. A 223 works only if you are shooting smaller hogs that do not expect you to ge near them. I have shot a few with a 223 in the less than 200 lbs range.
Handgun, a 44 mag or 45 with a heavy bullets and a modest accuracy load for recovery and follow up shots. The 44 with 240 grain hard cast SWCs will go right through a hog side to side and drops them in their tracks. The 44 do a good job in a rifle or handgun. I have a 444 Marlin and a 45-70 Siamese Mauser if I find big and deep tracks. I do hunt them down.

The 358 MGP with 200 RCBS plain base PCed, 300 BO w 230 Hard Cast PCed