You will find varying philosophies about this. I’m speaking as a shooter who spent 2023 learning and experiencing this stuff for myself. While I don’t have the deep experience of the other shooters here I do offer I’ve spent a lot of time taking in a variety of angles on this problem.
Among rimfire benchrest types, where pure accuracy is at the highest levels, the prevailing practice is to take the best shooting ammo you have for the gun, tune to make it the very best, and leave that tuner setting alone on that gun and barrel. This then makes other ammo lots shoot their best too. That said, this crowd doesn’t have much use for second-rate ammo and although wind effects are essential and critical, being 50y it’s less about wind than smallbore F-class that reaches to 100y.
My first attempts at tuning led me to a tune setting that varied a few clicks per each lot. I was warned by some who didn’t consider that to be a proper tune. I think they were right because the next week it didn’t seem to repeat. It is important to tune thoroughly and get to that one reliable all-ammo tune.
I also attempted to develop tunes using a few ammo lots I had on hand. I was unsuccessful at developing a tune to specifically make my mid rate ammo perform significantly better. I think part of the problem is less-than-excellent-shooting ammo makes the tuning process itself far more guesswork than progress. In theory that should be overcome if you shoot more shots during each step of the tuning process. I think the other part of the problem is that inaccuracy of lower performing ammo mostly comes down to things unrelated to tuning. It seems to me that tuning (50y, ten-shot groups) can take a 1/4” ctc group and make is 3/16” ctc, but it can’t take a 1/2” group and make it 1/4” or even 3/8”. So at the top end of accuracy that’s awesome but at the bottom end it’s hard to even detect. (The part I can’t reconcile about this, then, is why the wrong tuner setting can shoot much worse.)
There is always the underlying question of whether sorting ammo will improve its performance. Weight, runout, rim thickness, base to ogive, etc tools exist and the only way to know if they help is to do it and see. That said I don’t think most competitors do this most of the time. Again, your mileage will differ from anyone else’s. I just took delivery of a new lot of CenterX last weekend that I had a glorious weather opportunity to test yesterday, and it showed signs of brilliance (8-9 shots really tight and 1-2 shots that opened the group about 50%). Including the fliers it still shot good but I may do some serious sorting work on it to see if I can make it go from good to great.