I don't know about a 45-70, but do the math on a 200+ grain .30 cal at 1000 fps and 1010fps. The math says about 7" of vertical between the two at 500 yards. A .300 BLK is just plain slow, so you have to lob them. It's cool at short range because you lose almost no muzzle energy by the time you get to the target - they just don't slow down. But beyond a couple hundred yards, and you get lots of vertical simply due to muzzle velocity variation. It's just not designed for the task.
Ah, I hadn't done the math and didn't think there was that much vertical at 500Y with 10 fps ES.
My friends must have less than 10 fps ES?? because they can keep centerline-ish at 500M on Rams with blackpowder and those 535's. They have worked hard on their loads and they weight sort the bullets.