Yardage shot is always a consideration. Many of the shots are 375 yards and under, so compare the ballistics, somewhere around 450 is the break for heavies. Heavies do not give the launches that the lighter faster bullets give, nor the barrel life. I don't like to see them just flop over. I am usually trying to put some English on one to block a hole, shoot a head off, suck one out of a hole, flop one over on another one, but always trying to place my shot on the animal. I really hate it when I shoot one and 30 seconds he flops over on his back starting to ride a bicycle...bullet too tough.
In a 6 BR with H335 and the 55-65g bullets, you will get 8000 rounds on a barrel if you start off with a zero freebore still shooting groups in the high 2's at 8000 rounds but the copper fouling gets to be aggravating to deal with due to fire cracked bore. You don't have to take my word for it, Gene Harwood NBRSA Director sat a world record with a 6 BR in the mid 80's shooting his own 60g bullets with H335.
H335 works well with the 70g sierra blitz kings in the 6 BR with very, very long barrel life.
Using Hart, Shilen, Lilja barrels in 12 & 14 twists, I went 300 rounds in between cleanings on hot dog towns, shot them as fast as I could acquire target and pull the trigger, not to hard to shoot 5 shots a minute with a Right bolt/left port rig.
I have always wanted to have a 8" Twist chambered with a zero freebore reamer to shoot 55-70g bullets, just too many used benchrest barrels in 12-13T laying around that seem impossible to kill off.
I found that N133 and N135 eats barrels like you are shooting dried battery acid, that stuff burns HOT!