For purposes of this explanation, imagine that the bore of a barrel is a long continuous curve. Then imagine that you are setting this barrel up through the headstock so that the bore of the end that is being threaded and chambered is a close to coaxial with the rotational axis of the headstock as your equipment will allow, over a length of say 2 1/2" inches or more. Since the barrel is slightly curved, the only way to do this is to adjust the spider on the outboard end of the lathe is holding the CL of the muzzle end of the barrel offset from the CL of the headstocks's axis of rotation. This setup is entirely different than zeroing in both ends of the barrel. Depending on the amount that the bore curves, the muzzle end must be offset in order to achieve the desired alignment at the breech end. When the posters have referred to clocking a barrel, they are referring to the direction of the offset relative to the action, with the rifle sitting level. Not all smiths agree with this chambering setup, but I think that it is fair to say that different methods have produced winning barrels. The thought behind having the barrel clocked at 6:00 or 12:00 is that any straightening of the bore under the pressure of firing would be in the vertical plane, rather than inducing undesirable horizontal motion.