Joe,
I won't comment on the Shilen barrel life issue because there are certainly differing views on that subject.
The use of extremely slow burn rate powders is one strategy for the .243 Win case,and similar wildcats), and "overbore" cases such as the 22/250. However, I don't think it's accurate to say that powders such as H1000 and N165 will give the highest velocities.
For a standard .243 Win with a 28" barrel, shooting the 95 Noslers, H1000 and N165 are well down the list in terms of the velocity they can achieve at 60,000 psi,Max) and a 102% case fill,Max). Note the .243 Win is SAAMI rated at 60,000 psi. See: http://www.handloads.com/misc/saami.htm
A 49 grain load of N560,100.3% fill) is rated to 3325 fps velocity with the 95gr Noslers, 60K psi max. IMR 7828 SSC is rated to 3310 fps, 60K psi max. A 49.1 grain load of H1000,102% fill) is rated only to 3102 fps with a 50,061 psi, with a 97.3% propellant burn. [For comparison sake, the Hodgdon Online Load Manual H1000 max load for .243 Win and 95gr Nosler is 48.0gr COMPRESSED at 3077 fps]. A 47.7 grain load of N165,102% fill) is rated 3139 fps at 56,554 psi.
These are QuickLOAD projections and obviously reality may be different, but in general we've found the projections accurate within 30-50 fps,,and closer if we have the actual case capacity).
The "secret" of the slow burning powders in extending barrel life may not be so much in their burn properties as the simple fact that you cannot get enough powder in the case to reach maximum-rated pressures. ANY powder running at 50,000 psi is going to give longer barrel life than the same powder at 60,000 psi.
That's not to say best accuracy may not be achieved at those lower pressures with slower powders. I'm strictly talking velocity here.
But I think it's misleading to suggest you can drive a 95-grainer faster from a .243 Win with H1000 or N165 than with some of the other powders mentioned. If you look at various load manuals,not just QuickLOAD) you'll see you run out of case capacity with H1000 and N165 before you hit the pressure limit with a 95-grainer.