I will jump on the bandwagon here in support of the Grendel and will also say that the 6ARC is great as well.
I have two Grendels. One is a 24" Encore barrel that I have had for about 10 years now. It has accounted for a number of Axis deer, whitetails, and hogs. I liked it so much that I picked up a Ruger American Gen 1 Ranch chambered in Grendel to play with at the range and for hog work. It shoots way better than it should for it's price.
As has been stated, IMR 8208XBR is great powder for it and its availability is coming back. If you can't find any of that, LeveRevolution is proving to be a winner for this cartridge as well and has also been a bit more immune to the "powder inflation" that has been going on recently.
The good ol' 123 grain SST is a great bullet for both the bench and the field, however the 120 grain Hornady ELDM, the newer 100 grain Hornady ELD-VT, the 120 grain Sierra Prohunter, the 130 grain Sierra TMK, the 107 grain Sierra TMK, the Berger 130 grain VLD, and the good ol' 120 grain Nosler BTs are all very good choices for this cartridge as well. Some of these may require you to modify your mags (window them) to get them to fit and function, but that is an easy mod.
If you are a mono-metal bullet guy, then I recommend the 105 or 118 grain MKZ bullets from Cavity Back. They are designed to open and perform at lower impact velocities than your standard mono bullets (Barnes, etc.). Also, while I have no personal experience with them, I would have to believe that the lighter weight (80-110 grain) Hammer bullets would also be good choices for the Grendel.
As far as componets, as others have pointed out, Starline makes brass and has it available pretty regularly. If you do get into a pinch and don't mind having brass that doesn't have the correct headstamp, you can use 6 ARC brass as well. Just neck it up and shoot it.
All in all, the 6.5 Grendel and 6ARC are about as close to perfect for whitetail and black bear hunting East of the Mississippi. They are always on my list of recommendations for new shooters as well since the low recoil and muzzle blast makes for pleasureable shooting. Add a suppressor into the mix and it is sublime. I can pretty much guarantee that if the 0.445 bolt face was more of a standard offering the 6.5 Grendel would be one of the most popular rifle rounds out there.