I've had similar issues in the past... but mine were almost exclusively when trying to use a reticle that was too fine for my eyes. After pretty good success in 2007 with a NF 12-42x BR scope with a 2DD reticle, I thought 'hold small, miss small' so I switched to a CH-3 reticle (very fine lines with a tiny pin-prick of a dot floating in the center). About 5, maybe 10 seconds tops, and the reticle would fade away. I tried all sorts of stuff - look away, relax the eye, hydrate/lubricate the eye, different eyewear, etc. Long story short, having ~5 seconds to line up the gun, assess the wind, hold off and pull the trigger doesn't do anything good for your scores @ 1k. So I switched back to something a little thicker and easier for me to see.
I've had similar problems over the years with other reticles... and the manufacturers keep making the damn things finer and finer. Had a NF 15-55x Comp with a hybrid reticle (bastard child of a FCR-1 and a CH-3) that just killed me - had to use the hash marks to bracket the black bull and/or target frame, or else aim off in the white. Same thing earlier this year with a Vortex Golden Eagle 15-60x and the ECR-1. Luckily there are other reticle options out there, and I can usually find someone with the opposite reticle willing to trade pretty easily.
One thing I did notice, for me at least (though I think
@Lbart was the one who mentioned it first) is that just having a continuous line gives the eye something to follow all the way into the center. It's the reticles that have small gaps around the center, and then a tiny floating dot, that kill me. The 2DD, I could handle (I *love* that reticle)... but others, like the DDR2 and ECR1... no bueno, too fine. The center fades out, and I lose most or all of the reticle.
YMMV,
Monte