Hello Bobcat93, let me see if I can start the discussion here. Actually, that is a very good question, that is often asked in different ways, but always a good controversial subject.
Let me say right off that mirage (or rather, atmospheric distortion) can be used to your advantage if your know what to look for. Here on the Texas Gulf Coast, mirage is a fact of life 10 months out of the year, I think December and January may be mirage-free or poor, and sometimes February as well.
The neat thing about that shimmering we call mirage is that it can be a great indicator of what the conditions are at the place where you are observing it. Mirage is much more susceptible to change than flags and can also act as a precursor or portent to an upcoming change. Mirage will appear like a river in your scope and that appearance can be used to guage the strength of the prevailing conditions, at that distance. At the 1000 yard range, I like to focus my spotting scope at around 600 yards and my riflescope at the target line. Sometimes the shimmering is in the same direction, other times it is not and you need to know that and factor that in.
When the shimmering loses its appearance of a river, and starts boiling, this can be an opportunity to fire, or a sign to hold off. It's up to you to decide how to make it work for you. The boiling mirage will move the apparent target up some, so you may need to aim at a different location; again, this is something you learn and you need to experiment with.
In our neck of the woods, mirage will essentially stop being useful when the wind goes about 12-15 MPH. In fact the faster the mirage flows, the more difficult it is to guage and you may wish to rely more on the flags, but that's something for you to decide and get familiar with.
The best thing that I can tell you about shooting in a mirage is that you need to do it and learn. If it was easy, everyone would do it.
Lots of people power down their scope in mirage, others don't. Unless it's really horrible, to the point I can't make anything out, I do not power down, I want to see what's happening at the target line. You have to decide what works for you. Good luck.