I believe we are all talking about the same thing, just from different directions.
It all comes down to how many shots/effort you are willing to expend to obtain a verifiable/repeatable load. The whole system must be analyzed, not just the load itself.
This became apparent to me when I was a young sailor working as a computer technician in the navigation center of a ballistic missile firing submarine. The holy grail then (1970's), and still today, was Circular Error Probable (C.E.P.). Yes, accuracy is important even with nuclear warheads. C.E.P. gradually was refined to be an ellipse, mainly due to velocity and time of release errors.
Now, cannot C.E.P. be related to small arms group size? And cannot the C.E.P. ellipse be related to the vertical stringing at long ranges? I think so. As it would be very expensive to pull a nuclear sub off of the line and ripple fire 16 missiles with multiple warheads, a lot of high powered math went into figuring C.E.P.
Fortunately there is a less expensive and more efficient way available to us. Mean radius. Mean Radius is approximately 6% larger than C.E.P. but is much easier to calculate (this is becoming more important to me as I click off the years at a faster rate. I don't even buy green bananas anymore). The actual size doesn't really matter since we are looking for the smaller and
most repeatable combination.
So, how many shots should we fire to see how a load performs? Just as in racing, how fast do you want to go? How much money do you have?
Statistically, there is no difference between a five or six shot group. More than that and the precision is greater but the efficiency falls off. A four shot group is approximately 3% less efficient than five or six. If you intend to use "group size" (e.g., Extreme Spread) to estimate precision then you'll spend 13% more bullets shooting 3-shot groups to get the same statistical confidence. Hmmm... the NRA protocol of five groups of five shots seems to have been chosen for a reason and not just pulled out of err.... the air.
Personally, since one of my rifles is hard on barrels, I shoot five 4-shot groups. Since this is a hunting rifle and I want to be as close as possible to actual conditions, each shot is out of a cold barrel. This means at least 10 minutes between shots. Because of the timing, it doesn't really matter if I shoot 4, 5 or 6 shot groups. Four shot groups are easier to score than twenty shot groups when they overlap. So, I load up 20 shots and spend a day at the range. Since I number each shot on the target while waiting for the barrel to cool, that means 20 trips plus one to hang the target. I get my exercise which is my cover story to the wife unit for the credit card hits.
From my days as a High Power Rifle shooter, after a while, it becomes apparent that the human factor, from a practical standpoint, becomes the limiting element of the system. Probably the most important thing is to "Get Your Mind Right". Now for the Bench Rest shooters, bless their hearts, the part about "How much do you want to spend" becomes a bigger part of the equation, but "Get your mind right", I believe, is still the most important.
For a more thorough rendering of the mathematical aspect go to:
http://ballistipedia.com/index.php?title=Home
Please read the whole thing, including all of the menu items and the hot links.