My 22-250 is just the standard, not an Ack Imp, it wears a Brux barrel but mine is only a 12tw. It started out as a 24 but I had it shortened to 18 and I run it suppressed 100% of the time. It's definitely louder than it was before and even suppressed it's not what I'd consider hearing safe without ear plugs. A few shots, 2-3 maybe, without ear protection hunting coyotes isn't bad but if I'm out shooting it more than that in a short time frame I'll have some sort or ear protection in/on.
Mine only being a 12tw I shoot the 53gr Vmax but I also use RL17 and I'm right at 3600 in my 18in Brux.
The more overbore something is generally the more they loose per inch of barrel. You'll probably be closer to 35-40 fps loss per inch of barrel on a 22-250AI then 25 fps. With a powder like RL17 shooting 80gr ELD-M's from a 20in barrel a high end load will probably be in that 3250-ish range.
For what it's worth, a varmint/coyote gun that is being used suppressed all of the time, I will gladly give up velocity and a little added noise for a shorter more convenient and much handier handling rifle. A coyote isn't going to be anymore deader'er at 3250 VS 3400 with a 80gr ELD-M.