I guess it depends on what you're shooting groups for. I zero at 100, move straight to 300 and shoot groups. A 1" low or no wind group at 300 may be awful in the wind due to velocity.
A prime example is my 223, 55 grain bulletts shoot great at 100 one ragged hole. No wind at 300 1", increase the wind 3 1/2" and I can miss the head of a groundhog. 3,200 FPS.
New load 40 grain at 100 yards occasionally better than 1/2". The 300 yard groups no wind 1 1/16", windy days and the groups are 2". 3,900 FPS.
A prime example is my 223, 55 grain bulletts shoot great at 100 one ragged hole. No wind at 300 1", increase the wind 3 1/2" and I can miss the head of a groundhog. 3,200 FPS.
New load 40 grain at 100 yards occasionally better than 1/2". The 300 yard groups no wind 1 1/16", windy days and the groups are 2". 3,900 FPS.