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Primarily will run into pressure sooner (less velocity potential) the more the bullet is in the case.
Then there is potential of "donut" issues, if your brass is subjected to them.
Other then them, I know of no other issue's.
Donovan
As noted above by Donovan, it may not be optimal in terms of pressure (you're giving up a fair amount of usable case volume with the bullet shank sunk way down in the case). However, it is still possible to produce precise and consistent loads as long as you can maintain the optimal distance between the bullet ogive and the lands. Pull apart a commercial 77 gr SMK (.223 Rem) load sometime. You'll be surprised how far down in the neck the bullet is seated.
Yes, I have seated wad cutters too deep to do a proper roll crimp. I have seated bullets with cannelures too deep to crimp inside the cannelure. When I first got started with semi-auto pistols, I seated some bullets in 9mm cases that were too deep and the shells did not want to slide up the feed ramp and into the chamber. I have seated cast bullets too deep and have had lube melt and drip onto my powder. Leaves nasty squib loads and barrel fouling. On a wildcat 7mm, I seated bullets so deep, that bumping the bullet when chambering caused the bullet to move enough that neck tension on ogive cause the bullet to drop into the case further....not good on a bottleneck case.....
"too deep" can mean a lot of things....do you have something more specific?
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