If it's a sloppy chambered factory gun it's likely to be more of an issue than a custom job with a throat half a thou over bullet diameter.
I disagree and believe reality is just opposite.
There are various attributes with runout that are not the same. Most often runout is seen as crooked ammo, the side affect of a lot of FL sizing(not custom). This where the numbers get up to 3thou and beyond as measured at necks. That ammo does still shoot well in sloppy chambers, a perpetuating contributor to crooked, but not so well in tighter chambers.
Then you have a lower tier of runout (<2thou) from those who custom size and/or partial neck size with little to no body sizing. This is straight ammo with neck thickness variance and/or seating alignment issues.
This will shoot well in tighter chambers, and those tighter chambers perpetuate low runout. They will shoot well in sloppy chambers to.
Then you go to fitted chambers plus custom sizing, producing TIR as measured off seated bullets, below 1thou. A fitted chamber holds clearances at or below 1thou total -anywhere. I have one and can tell you that ~3thou TIR ammo shoots like sh*t in such a chamber. I tested this one day. it's a step change.
But again, the runout produced here is perpetuated, and there is no way to 'accidentally' produce greater than 1thou TIR ammo pulled from such a chamber. You'd have to heavily FL size or something. I skewed necks for my testing.
This tells me that the affect of runout to results is not about mythical alignment, but about chambered tensions. So while your runout and chamber clearances allow chambering without tension, the ammo will work ok. It passes tests.
Ultimately, straight ammo doesn't hurt a thing.