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Reloder 10x in 22BRX for varminting

Ive just picked up a tub of reloder 10x for my upcoming 20 practical loading as apparently its very good for 20 cals. But im just wondering if i can also use it in light bullet varmint loads in my 22BRX? I was thinking possibly 50gr nosler ballistic tips or sierra blitzkings- this rifle doesnt seem to like hornady bullets for some reason. Would i have trouble with them blowing up in a 1:10 twist 27' barrel driving them out around the 3900fps mark? Can anyone suggest any starting points for my powder charges please.

Cheers
 

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