The M1000, introduced early last year, is the replacement for the RCBS 10/10 which has been discontinued. The M500 is a direct replacement for the RCBS 502 which, along with the 505 has also been discontinued.
I've not seen the M1000 but I've had a couple of M500's. I would guess the mechanics of the two are the same except for the extra poise and capacity.
If you don't need to weight above 500 grains, I'd choose the M500, the extra poise, although some find it easier to use, is just another potential source where inaccuracies can creep in.
The M500 has exactly the same floating agate bearings and knife edge set-up as the familiar old RCBS range. The two major differences are the beam is printed on both sides, so good for lefties, and the magnetic damping plate is directly in line with the beam, rather than at a right angle - theoretically a better mechanical arrangement.
Another plus point is that the beam moment length, from the knife edges to the pointer is a little longer than the older range.
The body is lightweight cast metal, both the M500 scales I have worked on have been made in China but better quality than some of the Chinese made RCBS scales I've seen over the last 4-5 years.
The light weight can easily be addressed by filling the scale with Plaster of Paris, and a handful lead shot if you wish. The only real gripe I have is that, because of the ambidextrous nature of the scale, the pointer is well away from the scale beam, maybe 1/4 inch or so, this could lead to reading errors because of parallax problems - A simple webcam or use of a smart phone would eliminate this problem.
Here's an M500 I made an experimental beam for:
