This is an approach I've used:
First, if I'm looking for a powder with a certain burn rate characteristics, I go to QL and input screen for Propellant Table Setup to see what powders might interest me (like when I can't get the powder I really want):
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It'll provide a list like this:
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Then select a powder to use and will need to fire a few rounds to collect velocity data in order to tune the (Ba) burn rate in the app. Other data needed per what J_idaho listed for input to get good calculations:
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Then a list of various charge weights can be produced where one can see things like estimated Pmax pressure, case fills, velocities, barrel time. . . things that help decide where might be the best place to start load development:
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QL doesn't do all the load development work for you, but it does save on time and reduces the amount of components used to get to a good load.