I have a couple theories I've been formulating, as I slowly but surely burn through barrels on the dog towns. First, powder volume, or degree of overbore, is a much bigger detriment to barrel life than running high pressures. To use an example, you can take a 223AI and run it really hard (high pressures)...let's say 3,700 fps with a 53gn bullet and still get 5,000 rounds before accuracy falls off too much. Or, it seems to me, you can step up to a 22BR and run it at relatively moderate pressures to achieve this same velocities with same bullet, yet you'd be lucky to see 2,500 rounds before accuracy really starts to fall off. I've certainly not done any scientific double-blind studies here, just seems to me, you can run a moderate volume cartridge really hot and still get great barrel life...yet I've not seen overbore cartridges like a 22BR or 22-250 last long, even when pressures were kept low.
Second theory, I also believe there is a threshold you cross, in regards to case volume (relative to bore diameter) where increasing case volume past that threshold increases barrel erosion exponentially. In other words, to get an extra 100-150fps, you might but barrel life in half, or even 1/3rd. Take the mighty 6BR...I've burned out several barrels pushing 55/58 grain bullets HARD, yet I still get about 6,000 rounds of very accurate barrel life typically. But step up into a DASHER and run these same bullets an extra 150fps, and you'll likely get about 1/3d the barrel life. Big price to pay for crossing that 6BR capacity threshold. For the 22 cal, I suspect this threshold is somewhere north of 223AI capacity...go much above that, and watch out!