And in this very forum the photo below was posted and the OP stated he increased the load until he got ejector marks and then backed off 1 or 2 grains. Meaning he found the elastic limits of his brass and backed off, and this varies between the brands of cases and how long you want your primer pockets to last.
Years ago, I read an article by M. L. (Mic) Macpherson somewhere or other on cartridge design and wildcats. Mik noted that every manufacturer or handloading gunwriter like himself got enthusiasts turning up with marvelous claims for their modified 22-250 or whatever where the 31.3-deg double-radius shoulder and other relatively minor changes gave such an improvement in thermodynamic efficiency that the cartridge gained 200 fps MV.
In reality, if anybody bothered to test them, the 'improvements' gave little or nothing over the factory version but when the recipient asked for powder and charge details the cat was let out of the bag. These characters were invariably members of the increase-the-charge-until-the-primer-falls-out / prominent-ejector-marks-appear-then-reduce-charge-by-0.5gn school. As Mik pointed out these loads almost always exceeded proof pressures often by large margins and yes anybody can get a hefty MV increase through running crazy pressures.
I must say though that some company's data in some cartridges are puzzling - much of Vihtavuori's in 308 Win for instance. Tyro handloaders asking around on the range what people actually use are shocked to hear people are usually (and happily) using 45-46gn, sometimes even as high as 47gn N140 with 155s when Viht's maxima are 43.2-44.2 depending on bullet make/model. At one time, Viht's max N140 loads for the 155 Scenar were even lower, down in the 42s. The problem with this is that the word gets around that such and such a company always understates max loads to protect itself and people assume this applies to every cartridge and every powder which it almost certainly doesn't. ... and should never be assumed anyway.It's less common, but still occasionally applies that pressure signs and/or worryingly high velocities appear before reaching published max - that's what chronographs are for .... and bullet pullers.
Nowadays of course, many handloaders myself included, have another variable to add to the mix and increase the fun quotient - what QuickLOAD calculates. Having just reread my notes on testing some first go attempts in a long-throat 260 Rem late last year, of three powders used with the 142gn SMK, one (Viht N550) produced ~100 fps higher MVs than expected, and two (Viht N560 and Reload Swiss RS70) were the reverse under-producing by 100 fps. None showed pressure signs but the three rounds with the highest charge weight of N550 went home unfired and were pulled as almost certainly going to be over-pressure.