I guess the .250 AI is an example of magic ballistics. The Nosler manual has the .22-.250 case holding 40.9 grains of water and the .22-.250 AI case at 46.3 gr. H2O. This is a good approximation of what might occur with the .250 & .250 AI. It is a 13 % increase. Doing the 4 to 1 thing: gives a 3.25 % velocity increase over the tapered slopey shouldered .22-.250. Or, for the .250 AI, 1.0325 * 3000 = 3097.5 ~ 3100 fps. Yet everybody knows the .250 AI is a mini power house, the best of the AI family and must get 3200. My guess is if 3200 is achieved is at pressures greater than 60K psi and with slower burning powders like H4350. A fat charge of H414 with 87's would really drive a bullet out fast. Any published velocities & pressures? I could not find any published data on-line that gave more than 3100 or so for the .250 AI with 100's. If 3100 is the limit with 100's the 4 to 1 stuff is right on.
https://loaddata.com/Cartridge/250-Savage-250-3000-Ackley-Improved/3099
The Speer manual gives 3000 with 100's using CFE223 for the standard .250 .
This gets into the "over bore" cartridges. My guess is with newer powder formulations the pressure peak might be flattened allowing greater velocities for giant capacity rounds. In this case the 4 to 1 rule might have more of an application. The new Re 26 might be an example of getting max velocities with allowable pressures.
I would like to know how accurately Ackley measured his velocities and pressures.