I've been playing with heavier bullets,JLK 108 & Berger 115 VLD)in a 250 AI recently. The rifle is a trued SA 700 with a 26" Krieger 10-twist in #5 sporter contour, Jewell HVR, custom sloped scope rail, and a Bushnell 6500 Elite 2.5-16x42 in Leupold PRW rings, all in a B&C Medalist stock.
I'd bought an 8lb. jug of 4007SSC not long after it first came out, hoping to use it in a 6 HAGAR upper, but it's way slow for that little cartridge, even in a 28" bbl. Seems a little fast with 115s in the 6x47L, so I'm hoping to find a niche for it in the 250 AI. No chrono data, as it was too late in the day when I finally made it to the range, but 38.5grs of 4007 with F210 & a moly'd B115VLD jammed .015" gave easy bolt lift, and five shots went into .7". I'll chrono the remaining five rounds before making the decision to bump the charge.
Also had 41grs. of H100V loaded with the same bullets & primers as above, but bolt lift was pretty stiff, so I fired only three rounds. I'll back it off a full grain before testing again. The kicker was that two of the three shots went through the same hole; hopefully, that wasn't a fluke, and H100V will perform just as well at lower pressure.
This 250 AI is somewhat of a paradox - Varget pushes JLK 108s 3000+fps w/o signs of excess pressure, while N160, RL17, & RL15 all topped out well under 3000fps. Definitely need to get the chrono out when I go back to try H100V & 4007 again.