Maybe some clarification would help. I developed that load in the early 2000s and still use it today. I started reloading in 1993. Yes, there's lots of load data available from the manufacturers, a lot more today than there was in 1993. Still, it's surprising, even depressing at times, just how many gaps there are in the data even today. For instance, last time I looked, I couldn't find published data for using N133 behind a 53gr .224 Vmax. Even more discouraging is how much variation there is for the exact same load that's published by multiple sources (Hornady vs Hodgdon for example).
I've used 22 lr to dispatch coons and groundhogs in the past. Problem is that the animal doesn't always die where I shoot it. Under 75yds its pretty easy to get a headshot, but 75 - 100 yds, getting a headshot on an impromptu encounter is more iffy. I want it dead on the spot so I can dispose of the carcass instead of having to smell it rotting from its den for the next 3 weeks, or drag itself under the neighbors deck (they call me to deal with their pest issues). I also want the bullet moving fast enough on impact to ensure rapid expansion. I don't want a 22lr slug that holds together if it only encounters soft tissue.
The reason I chose green dot at the time is that the lowest charge I ever tried still filled the 223 case over half full, and that charge was safe to use with a 230gr 45acp which has a max allowable pressure of 21,000 psi (less than 1/3 the pressure a 5.56 is rated for). I completely understood that pressures can increase drastically with very small changes in volumes, so that published 45acp load was my starting point. My main concern was whether or not the load would generate enough pressure to even properly ignite since it was only pushing a 40gr vmax. I tested from 5.5 gr up to 9.0 gr in small increments, checking the brass and primers along the way with no signs of pressure. We've now used thousands of rounds of this load on prairie dogs with great success. I've tuned this load for 4 different rifles now, and found that all of them had a sweet spot between 7 and 8 grains.