Heck, this thread proves it -- there are so many good guitar players out there that it simply must not be very hard to do.
That's a lie, and I know it because I've tried. I grew up playing the brass instruments, and was good at it, but guitar never worked for me. It seems like the guys - or gals - who can do it, become a part of the instrument, and work together with it more than simply operating it. The closest thing I've done that feels like that, is operating my boom truck with two 4-way joysticks, and foot pedals. - hydraulic controls, not electronic.
I had a pretty fair guitar once and wound up giving it to a buddy who was a hopeless tweeker and had lost his to the pawn shop. He was amazing with a guitar, and could play anything with anybody. I didn't have much in those days, but I couldn't bear to see that guy without a guitar.
I sometimes wonder if I should try it again. Then I take a look at my hands.

jd