I've have a few questions.... 1. Does it pay to vary seating depth and different powder weights together?
Answer: No. I prefer a methodical approach such as this where each element is segregated:
Working Up a Load …. by Lee Euber
1. Polish bullet with steel wool. Initial seating depth achieved when bullet is marked by all lands. Tony Boyer likes to see a “square.” (Boyer's comments added for my reference.)
POWDER
2. Load 3 cases in a low grain load. Increase each 3 case load by .5 of a grain, and then shoot. Increase loads until primers show pressure.
3. Identify shots that grouped well, not so good, and then good again.
4. Pick load that shot the best. Load 3 cases with .1 grain less, and 3 with .1 grain more, for another comparison.
5. After picking charge for use, load 30 cases with the same powder charge.
SEATING DEPTH
6. Load the 30 cases in groups of 3, increasing the seating depth from touching the lands to jumping about .040 of an inch, in increments of .005 of an inch.
7. Shoot all 30 rounds without cleaning or clean after each 10.
8. Use ONE fouling shot after each cleaning.
9. Select load that shot best. Load 5 cases with that powder charge and seating depth.
10. Load 10 cases, 5 with seating depth .005 less than benchmark figure and 5 with .005 more.
11. Can compare more than once or change seating depth by .001 or .002.
12. Once you’ve picked the best seating depth, load 15 cases at that depth.
POWDER
13. Check first test by varying charge by .1 grain, for each 5 shot group.
14. Shoot in a medium wind condition, letting the gun do the work.
SEATING DEPTH
15. After picking the best load jumping the lands, compare it with the load that touches. Compare these loads again and again, on different days, in varying conditions, deciding which one is best.
16. If it doesn’t shoot to your satisfaction, restart with a different powder.
NECK TENSION
17. If you decide on the load that puts the bullet in the lands, be sure neck tension is tight enough to hold the bullet uniformly.
2. When we find a load that works, is it the weight of the charge that's perfect for that gun or the velocity that was produced under the testing conditions?
Answer: It was all the above used in the tune that made the difference in the barrel's tune. Velocity is just a byproduct. In other words you don't tune with velocity, but you can record the tune's velocity for whatever it's worth, for example, for statistical purposes.