If the OP is using factory Corelokts, tuning isn't something he's worried about.
My experience with the 30-06, has repeatedly led me to one bullet.
The 165gr Nosler Ballistic Tip.
From 20 yards to 320 yards, the deer was always found where it was shot.
Now after 30+ years of hunting the 30-06 is gone, but the Ballistic Tip is still my go to bullet for hunting.
I've seen 2 instances where the 150gr, 30 caliber Corelokts (essentially Hornady Interlocks)
failed to perform with 5 & 6 shots in the vitals.
First was doe a friend and I found that was already gut shot.
He had a doe tag, so decided to take it.
30 foot shot with his Savage 99 in 300 Savage.
Deer went down. He started walking up to it. Deer got up & he put another round in it.
Down, up, bang, down up, bang, down, reload, up.
I finally had enough, and dropped it for good with a 7mm, 140gr Ballistic Tip to the head.
Doe had 1 gut hit, 5 chest hits, and 1 head shot.
Following year, my neighbor invited me to hunt with him on his family's property.
Buck came in, he shot 30 yards with his pump action 30-06.
Buck stopped and stood there looking around after the shot.
He hit it again. Deer walked 20 yards to the side. Bang, hit again.
Reload.
Again, I had enough finally, and head shot it with my 7mm-08 AI.
Dear had 6 chest hits and 1 head shot.
My experience with the 30-06, has repeatedly led me to one bullet.
The 165gr Nosler Ballistic Tip.
From 20 yards to 320 yards, the deer was always found where it was shot.
Now after 30+ years of hunting the 30-06 is gone, but the Ballistic Tip is still my go to bullet for hunting.
I've seen 2 instances where the 150gr, 30 caliber Corelokts (essentially Hornady Interlocks)
failed to perform with 5 & 6 shots in the vitals.
First was doe a friend and I found that was already gut shot.
He had a doe tag, so decided to take it.
30 foot shot with his Savage 99 in 300 Savage.
Deer went down. He started walking up to it. Deer got up & he put another round in it.
Down, up, bang, down up, bang, down, reload, up.
I finally had enough, and dropped it for good with a 7mm, 140gr Ballistic Tip to the head.
Doe had 1 gut hit, 5 chest hits, and 1 head shot.
Following year, my neighbor invited me to hunt with him on his family's property.
Buck came in, he shot 30 yards with his pump action 30-06.
Buck stopped and stood there looking around after the shot.
He hit it again. Deer walked 20 yards to the side. Bang, hit again.
Reload.
Again, I had enough finally, and head shot it with my 7mm-08 AI.
Dear had 6 chest hits and 1 head shot.