Toby,
Most if not all of the distribution information was gathered by testing for military purposes, which means that in terms of really fine accuracy, the results are generally useless because none of us shoot rifles that are that inaccurate, or one size must fit all military loads, in chambers with military clearances. On a day with excellent conditions my results on target, track pretty well with the changes that I make testing loads. Let me give an example. One time I was being less than rigorous about coming up with a starting load for a new powder, and the conditions were good, and I had about a bullet hole of paper between the two bullet holes. Believing that for the caliber, components and rifle type that I was shooting, that nodes have about a 1.2 grain spacing, and noting that the two shots were about as bad as I normally see under those conditions, I guessed that I was about half way between nodes, knew that going up .6 gr would result in excessive pressure, so I set my measure to throw .6 less, and the bullets overlapped by more than half of their diameter, with the offset being all horizontal, where the previous two had been on a diagonal line in the same conditions. From there I began more extensive testing, and the results were consistent with the differences seen in the flags. Personally I think that that demonstrated more than a crude estimation. It was calculated based on best information, and it worked. This is not to say that that sort of change always works. On another day, I had shot a group with a load that came from my notes, based on what had worked well in similar ambient conditions, and all it gave me was a blob. No paper between shots, but about as large a group as can be had without any. I tested .3 up, and .3 down and the results were no better. At that point, having faith in the rifle, and needing to try a different approach I dropped my load to the next lower node, and it came smartly together, and shot that way for the rest of the afternoon. For me is is not about the sample size but the measuring instrument, and the consistency with which what is being measured is produced, both the ammunition and the shooting.
One reason that I have no desire to shoot rimfire benchrest is that it would require a lot more rounds down range to come to a reliable judgment, because I would be at the mercy of ammunition manufacturers. I have a friend who has a number of perfect score targets to his credit, and so I am aware of what it takes to excel in that sport. He has put a large amount of time and resources into getting to his current level of expertise, and even so, continues to experiment.