Absolutely!
I have been loading for OBT since 2014 and have kept extensive data on all the rifles I have loaded for.
There are a few things that you need to be aware of. As a indication of what extensive means, I have loaded over 78,000 rounds since 2,008 and have measured 14,000 5-round groups and recorded all of them.
Things to remember about OBT:
First, temperature can change powder velocities and change OBT so you need to be cognizant of that.
Second, OBT changes with the type of barrel steel.
Many barrels are 0.3% carbon - reflection speed is 19,107 fps.
Pre WWII barrels are often slower 18,916 fps.
Vanadium steel barrels (1040 and 1050 steel) often called chrome steel are 19,969 fps.
Stainless Steel barrels are 20,000 fps.
416R SS barrels are 20,014 fps.
Third, the 'published' barrel length will change the actual OBT. I have barrels that are up to 3/8 inches longer or shorter than the published length. 16 of 42 barrels I calculated for are not at published lengths. You have to measure to find your actual OBT.
Fourth, changes in Seating depth of 0.002 with identical powder loads will change OBT by 0.001 msec. Changes in trim length or 0.002 with identical powder loads will change OBT by 0.001 msec.
Fifth, the OBT occurs when the shock wave is at the chamber (an even number of reflections) rather than at the muzzle (an odd number of reflections) to minimize the harmonics and keep the crown tight when the bullet is leaving the muzzle. Normally, since the reflection velocity is much faster than the speed of the bullet as it accelerates down the barrel, the OBT can be between 10 to 14 reflections. I generally find that for light bullets the 10th reflection might work but for heavy bullets the 10th or sometimes the 12th reflection is over or very close to PMax pressures.
I have found that there is no statistical change in accuracy for Exit Time changes versus OBT that are around +/- 0.005 msec. that I can determine accurately. (My shooter induced variations probably cause that).
It sounds complicated, but I have found I can get a new barrel close to node by calculating and loading for exit time at OBT in the first session. I generally, load 5 rounds on OBT, and 5 rounds + or - 0.005 and 0.010 msec. off OBT, each, to see if the calculated setting is right on. (I don't assume my measurements account for all the variations that might be related to a specific barrel.)
I find that there is about 0.090 inches change in group size at 100 yards between the Exit time at the chamber and the muzzle.
It took me over a year of improving my consistency in shooting after I accounted for minimizing the 5 items listed above to be able to actually see and measure the effects.
The last 'aha' was finding that temperature changes were messing up my calculation of exit times because the powder was either burning slower in cold or faster in the heat. Fortunately, temperature was one of the things I measured and recorded, so I redid my calculations for hundreds of sessions and all the data was adjusted and became clear.