Recently loaded up some new rounds to be non lead compliant. I'm shooting weatherby vanguard 300 win mag. I took the information directly from the nosler website. 180 gr e-tip, 79gr H1000. It was amazing how much of a difference these loads where from factory rounds, but got it zerod at 100, then 200, with nice round holes. But once I shot out to 300 I had a keyhole. I'm lost....my only thought is to go smaller on the powder. My vanguard has a 1-10 twist, which is also posted on the nosler website. Any help is appreciated