I shoot quite a few coyotes and when I still had my property I killed many off of bait. I got the idea that I would shoot a subsonic 300bo, with the theory being that I could kill more than one per night as the coyotes would not disappear after the first shot.
I spent a considerable amount of time developing a load that would produce MOA accuracy. I finally succeeded with a load that was accurate, 220gr sierra matchkings, sorted brass, etc... I had coyotes on the bait, I shot the first one right through the chest at about 100 yards, both coyotes disappeared. I went out to collect my kill and found a very minimal blood trail in fresh snow. I tracked that coyote for over a half mile and never caught up to it. A few days later, I try again, same thing. Decent blood trail, but after several hundred yards it got onto property where I could not follow it. It happened one more time before I gave up on that setup. If there had not been snow, I would have thought I had missed.
I looked up bullets that would expand at subsonic velocities, my recollection is that the projectiles alone were about $1 to $1.50 each. It took me well over 100 rounds to find the accuracy load with the sierra. I was not about to spend $150 on components to maybe find an accurate load again. Especially considering that the idea of not scaring off the other coyotes was a bust. I use a suppressed but supersonic 223 now. I only get one shot off, but they are dead on the spot, I have even killed 3 in one night, just a couple hours apart.
But, if you still want to proceed with a 300BO, I have a D-Tech built 16" threaded upper for sale with only a couple hundred rounds through it.