Hi Knot,
I had the same problem with my 243 AI for a while. It also was a 1-10 twist and 20" bbl. I tried 17 different powders and several different bullets from 62 to 80 grains. The 3rd shot would always have a mind of its own. H-380 and Varget produced the best groups in that bullet weight range. H-414 produced erratic pressure signs in my rifle. My groups tightened up .4" after varying the seating depth to find that sweet spot. That was the best I could get out of it. It is at Hart now getting a fresh barrel for next varmint season. Good luck.
I had the same problem with my 243 AI for a while. It also was a 1-10 twist and 20" bbl. I tried 17 different powders and several different bullets from 62 to 80 grains. The 3rd shot would always have a mind of its own. H-380 and Varget produced the best groups in that bullet weight range. H-414 produced erratic pressure signs in my rifle. My groups tightened up .4" after varying the seating depth to find that sweet spot. That was the best I could get out of it. It is at Hart now getting a fresh barrel for next varmint season. Good luck.