Mike in Oregon
Gold $$ Contributor
I need to make up my mind on what size primer pocket to go with for varmint hunting on both my 22 & 6 Creedmoor. I will be shooting light bullets in both, if that matters. 
Mike...

Mike...
Mike -I need to make up my mind on what size primer pocket to go with for varmint hunting on both my 22 & 6 Creedmoor. I will be shooting light bullets in both, if that matters.
Mike...
Preference?Small magnum
I only use Cci450. Over the past 5 years they have been more available than large primers. The large primers are making a comeback.450's are my favorite.
A hang fire is very unusual and very dangerous.Note that I have had some hang fires using small primers.
Nope, hang fire. There were some powders I was trying that just didn't work. Accuracy was great, velocity was low, but there were some "click bangs". RL-15 and 7 1/2's in Lapua SRP brass were the worst combination.A hang fire is very unusual and very dangerous.
By chance do you mean FTF. ( failure to fire?)
Open up the flash hole a bit and I bet that disappears…Lapua has the smallest flash hole of them all.Nope, hang fire. There were some powders I was trying that just didn't work. Accuracy was great, velocity was low, but there were some "click bangs". RL-15 and 7 1/2's in Lapua SRP brass were the worst combination.
Ah yes, that is VERY true. If the rifle is based on the Win 70 action with a .080+++” firing pin tip, shoot large rifle. If not you will blank every small rifle primer you shoot. Even mild loads punch a perfect circle in your primers. Been there done that on a 6x47 Lapua. After bushing bolt face to .070” or so and turning firing pin to match all was well again.To the OP’s original question, it will depend if your firing pin and it’s sleeve is small enough to handle the srp.
That would remove a primary reason for using Lapua brass.Open up the flash hole a bit and I bet that disappears…Lapua has the smallest flash hole of them all.