I have had a few 22/250 AI's, 12 twists Harts. Also, one rem sporter rechamber, shot well.
In our predator calling club in S. Ca. there were probably a dozen guys that shot this round. Out of those 12 guys, 10 shot win 760 with 55g Sierra or 55g Nosler bullets, velocity at 4050-4100 depending on the barrel.
Another guy shot H380 with the 50's, and another shot H414 with the 55's. IN those days, H414 was about .5g slower than win 760.
So, I in minimum freebore with a 27" barrel, I also shot the Berger 60 and 65g flat base(65 no longer made). 37g of Win 760 got me 3700 fps with the 65's, it is a very high pressure load that required F.L. sizing after every firing, but accuracy was in the low 2's. I actually shot a bob cat in half at 100 yards with the 65g at 3700.
Now, you jack up the twist rate, figure increasing pressure another 10% at least, so if you try 760, back way off these loads that I mentioned.
R#15 works real well with the 50g Nosler, I have good load for my current two rifles with it, but the accuracy node is also on a high pressure with speed in the 4050 fps in the re chamber'd Rem 22/250 Varmint and accuracy is outstanding.
If you want to shoot medium pressures with extreme accuracy in the 22/250, good luck. I would just go out on a limb and say that in my experience, it never happened and I shot with a lot of guys with custom 22/250 AI's and they all liked 95% full throttle or higher.
I played with IMR 4064 and IMR 4350 just a tad with the 55g Ballistic tip, got fantastic accuracy, but what a pain those stick powders are.
The 22/250 AI is my favorite coyote round, hits like a sledge hammer with Sierra 55g what evers and the Nosler 55g.
I quit shooting the 50's when I had an incident happen. Larry Z. and I were up in S. Dakota wearing out a dog town. I was zero'd in on a party that spread out from 300-325, had the target knobs dialed in for minute of p. dog head. I shot one p. dog, he flew up in the air doing helicopter gyrations. All of a sudden, a coyote runs up and is on the p. dog just as it hit the ground. I slammed another round home, and while the coyote had his mouth pointing up toward the sky, trying to guzzle down as much p. dog as he could without choking, I put the fine cross hair right across the bridge of both eyes. At the report of the gun, he went out of sight and that resounding, PLOP was heard, just like the bullet had hit a brick wall. Larry and shot till we got tired, then walked over to take a look at the coyote. He still had pieces parts of p. dog in his mouth, and the bullet hole (50g Nosler at 4200 fps MV) had entered the skull about 1 1/2" to the left of point of aim, right above his left eye. The bullet had not exited the coyote's skull! Now at 325 yards, the bullet had slowed down, but it turned me off on penetration for a coyote round. So, I went back to the Nosler 55's and the Sierra 55's FB, SptBT, and the 55g BTHP. I like a bullet that will break shoulders, hips, ribs and put them to leaking on the off side.