Hillbilly -
Howdy !
I loaded for, owned, shot... a lot of   various  regular .22-250s... both factory  and  customs.
I also shot a  .250 Savage, and a  .224" caliber wildcat of my own design   ( .35Rem necked-down to .224" cal ).
The .22-35 has case capacity between that of  .22-250  & .22-250AI.  I shot the  .22-35 in both a  24"  1-14 SS Hart, and a
28"  1-8  SS   K & P.         Based on those experiences, might I say:
IMHO... your powder choice features a burn rate that is too fast, to provide best internal ballistics efficiency w/    your case/ your rifle.
Higher load densities ( than you'd get w/ IMR4320 ) are possible....
For .22-250,  IMR4064  was in the zone  w/  55s ( 24" barrels ) .... to give an idea on burn rate.
For   75s  in the  .250 Savage  ( 22" barrel ),   H380 worked really well ( my load/my gun ).
When I went to use of the larger-capacity  .22-35, powders that  worked superbly ( for me ) w/ 55's  were  WW760,  IMR4350; and VV160.
This is a cluster of similar burn rate powders, that are also  " slower " than IMR4320  &  IMR4064 ( for example ) you'll note.
I got into the 500yd club shooting the 24"  .22-35, using a load of  41.6gr  VV160 & FED LR Magnum Match;  under prototype  55 "V"-Max.
With the  28", I shot  75 "A"-Max exclusively for both  varmint  & target work.  My favorite combo accuracy/field  load was:
40.5gr  AA3100  &  FED LR Match  under the 75 "A"-Max.   As you'll again note,  the powder choice was slower in burn rate still,  than what I used  w/ the lighter 55gr bullets.
If you're one of those shooters that wants  peak vel,  you might very well settle on " Varget ".   A lot of  shooters do.  
I  myself don't bias  obtainable vel  FIRST , or even have a  finite vel  target established ( for my shooting needs ).   
I  prefer to find & use the best possible accuracy loads,  that  also give me useful vel.   Again, that's  to meet  my  shooting needs.
I'll admit that nearly all of  my best  accuracy rifle results have come when shooting  load densities  from  93 - 100%  ( .224" cal  & 6mm ).
My point:
I strongly suggest you consider trying-out powder(s)  that get you into a higher load density range; than what  IMR 4320 can provide. 
With sincere regards, 
                                         357Mag