Hillbilly -
Howdy !
I loaded for, owned, shot... a lot of various regular .22-250s... both factory and customs.
I also shot a .250 Savage, and a .224" caliber wildcat of my own design ( .35Rem necked-down to .224" cal ).
The .22-35 has case capacity between that of .22-250 & .22-250AI. I shot the .22-35 in both a 24" 1-14 SS Hart, and a
28" 1-8 SS K & P. Based on those experiences, might I say:
IMHO... your powder choice features a burn rate that is too fast, to provide best internal ballistics efficiency w/ your case/ your rifle.
Higher load densities ( than you'd get w/ IMR4320 ) are possible....
For .22-250, IMR4064 was in the zone w/ 55s ( 24" barrels ) .... to give an idea on burn rate.
For 75s in the .250 Savage ( 22" barrel ), H380 worked really well ( my load/my gun ).
When I went to use of the larger-capacity .22-35, powders that worked superbly ( for me ) w/ 55's were WW760, IMR4350; and VV160.
This is a cluster of similar burn rate powders, that are also " slower " than IMR4320 & IMR4064 ( for example ) you'll note.
I got into the 500yd club shooting the 24" .22-35, using a load of 41.6gr VV160 & FED LR Magnum Match; under prototype 55 "V"-Max.
With the 28", I shot 75 "A"-Max exclusively for both varmint & target work. My favorite combo accuracy/field load was:
40.5gr AA3100 & FED LR Match under the 75 "A"-Max. As you'll again note, the powder choice was slower in burn rate still, than what I used w/ the lighter 55gr bullets.
If you're one of those shooters that wants peak vel, you might very well settle on " Varget ". A lot of shooters do.
I myself don't bias obtainable vel FIRST , or even have a finite vel target established ( for my shooting needs ).
I prefer to find & use the best possible accuracy loads, that also give me useful vel. Again, that's to meet my shooting needs.
I'll admit that nearly all of my best accuracy rifle results have come when shooting load densities from 93 - 100% ( .224" cal & 6mm ).
My point:
I strongly suggest you consider trying-out powder(s) that get you into a higher load density range; than what IMR 4320 can provide.
With sincere regards,
357Mag