When i started to work up a accuracy load for my 6,5-284, i ran into some difficulties.
I'm from the other side of the pond, so a lot of the stuff you guys are using, are simply not available here, especially primers and powders!
So, i started to do some comparing and tried with Vitha 550 and reload Swiss RS 62 ( the latter is very close to 4350 in burn characteristic ), but i could not get the velocity i wanted.
Slower is sometimes better, so i moved to RS 70 ( close to RL 26 ) and 54 grn are sending a 135 grn A-Tip from home with 930 m/s ( 3051 FPS ), with a remarkable accuracy ( 0,3 MOA ), but the ES was way to high, for any use on the long range.
My first loads was with CCI 250, ES was 55 Fps, not good enough, Federal Magnum fared a bit better, 30 Fps and Rem Magnum 35 Fps.
I was starting to get desperate, but then i found some VERY old Ruag 5333 i a drawer and the ES dropped to a mere 9 Fps ( 10 shot string ) the group shrink to 0,2 Moa.
I sourced all the 5333's i could and ended up with some 5 K and made another load with 140 SMK over 52 grn RS 70 is used for practice, but are still holding 0,4 Moa ( see the picture ).
So yes, primers matters, but what's good for one powder, may not be usable for another.
Just my 5 cents