Man, this thread really grew a long pair of legs! Nearly 5 years with members still interested in offering their opinions.
Fortunately, there are several thread from the recent to the last few years offering information regarding the .250 Savage and how it performs. Two drawbacks to the older rifles are the slow twist rate and the much lower pressure based on the platform being used. Now, don't get all excited and frothing at the mouth to crucify me, these rifles still work and harvest deer every year, just work with the restraints.
Instead of the hand wringing about lack of brass, Hornady does make it and it is available currently. It's fine for the lower pressure platforms since Hornady brass is soft to begin with and the lighter loads will work perfect. In that same vein, Prvi Partizan makes .250 Savage and it too is available. If you are lamenting the lack of quality brass, Lapua .22-250 will make perfect 250 Savage with a final forming following necking up. I wound up with a good supply of Lapua .22-250 brass so I supplemented my diminishing supply of 250 Savage by modifying those cases.
If for some reason none of this appeals to you, I seriously suggest using something currently available such as the 25 Creedmoor. Yes, I know, I've read all the slanderous posts regard these fine cartridges. But the 25 Creedmoor loaded with your favorite bullet and appropriate powder choice is nothing short of superb. Besides, the modern alloy brass and forming processes make this an excellent choice. If for some reason you dig in your heals at the mere mention of anything Creedmoor, you have only your self to blame for missing out. It's fine, you leave more for the rest of us to buy.
Another well thought out wildcat is the .25x47 Lapua. This can make for an excellent shorter barrel, lighter carbine-style rifle for our members of smaller stature. It's mild in recoil yet accurate when the rest of the platform is handled correctly by a qualified gunsmith.
Lots of choices when the nostalgia wears off and you want to move on.