Another way to think about the same question is in the context of exactly what makes up a "hummer" barrel. Hummer barrels show up in [lucky] people's hands from time to time, and seem to outperform what should otherwise be identical barrels from the same manufacturer. These barrels seem to tune very easily, with extremely good precision, and seem to give tuned loads with various bullets more wind resistance than they should theoretically have. If anyone knows with absolute certainty what constitutes a "hummer" barrel, I am not aware of the explanation. However, one theory that has been tossed around is that bullets leave the bore of a hummer barrel with slightly less yaw/pitch than they would out of an otherwise identical barrel that is not a hummer. Because of that, it has been suggested that the bullet may actually behave as though it has a higher BC than the box value would indicate.
I have no evidence whether this theory is correct, but it does seem to be in agreement with other theories regarding barrel twist rates and "effective" bullet BC. If a bullet is fired from a barrel with a sufficient twist rate to gyroscopically stabilize it just enough to prevent keyholing or other phenomena associated with gyroscopic instability, it will typically behave as though it has less BC than it actually does, partially due to more pitch/yaw straight out of the muzzle. According numbers commonly used by Bryan Litz and others, this would mean gryoscopic stability coeficients somewhere in the neighborhood of perhaps 1.2 to 1.4. Sg values of around 1.1 or less is where you start to observe oblong holes in close range targets, or even bullets going sideways through the target (keyholing). According to Litz, if you increase barrel twist rate until an Sg of 1.5 or greater is achieved, that will help dampen pitch/yaw as the bullet exits the bore and allow the bullet to fly with its full intrinsic BC. The point being, the effects start as soon as the bullet leaves the bore, or possibly even before the bullet leaves the bore. Anything that alters bullet behavior that early in its trajectory will have an even greater effect at the target than something that affects its trajectory equally, but much closer to the target (i.e. farther downrange). That is why I stated earlier that the effect of changing BC can be observed on bullet trajectory very early in flight, and is essentially taking place as soon as it leaves the bore.
It is certainly much easier to shoot smaller groups at 100 yd than at 600 yd in perfectly calm conditions, but that is largely due to a decreased effect of angular dispersion at a shorter distance. In other words, if group spread is your Y-axis value, reducing the distance shrinks effectively down the magnitude of the Y-axis values. Nonetheless, it is not difficult to observe a difference in group width (windage) in moderate to strong wind conditions, even at distances of only 50 to 100 yd, between two bullets with markedly different BCs, such as a lightweight .224" 52 gr bullet and a much heavier (higher BC) .308 200 gr bullet. The differences in their trajectories begins as soon as they leave the bore and are subject to the effect of the wind, even if there is some minimum distance, closer than which it is not easy for us to discern the difference.