Bart since you do not subscribe to the standard concepts of defining a node based on poi sensitivity minimization, I would be interested in knowing your theory and procedure.
Load Development for Factory Barrels
1. Ensure rifle's ready; barrel 100% free floated clear of fore end.
2. Use bullets with diameter at least .0003" more than barrel groove diameter and weight in upper weight range for barrel twist.
3. Use new cases or full length sized fired ones whose shoulder's are set back .002" and die's neck is .002" smaller than loaded round neck diameter.
4. Use stick powder about 2/3 to 3/4 up speed range of those listed for bullet weight. Charge weights 2/10ths grain spread maximum.
5. Use primers favored by competitive shooters using the same cartridge.
6. Seat bullets so COAL is 1/16" less than magazine length or to have 1/32" jump to rifling for single round loading.
7. Load 2 rounds at starting charge weight listed, then 2 more in 1 grain increments up to maximum. Test these to find two weights safe at upper range.
8. Most folks shoot smaller groups slung up in prone with the rifle resting on bags; one under fore hand and one under stock toe. Shouldered rifles on bags atop benches are not too repeatable from shot to shot.
9. Load 20 rounds of each then test them in 20-shot groups at desired range. Measure extreme spread or calculate mean radius from group center.
If shots start walking in some direction as barrel heats up, fix the rifle or shoot at a slower rate. If you cool the barrel, the odds of the rifle shooting to same point after getting back into the exact same shooting position are slim. Us humans are not 100% repeatable going back into the same shooting position after getting out of it.
Go with most accurate load.
That is pretty much how a few of us developed a load for Sierra's new 155 grain Palma bullet for 308 Win ammo. Several thousand rounds were loaded for its first use in a match wherein everyone shot the same ammo from prone with metallic sights. It shot about 3" or so at 600 yards in a couple dozen rifles with different barrel profiles; as reported by these top ranked competitors. I got razzed a bit having shot the high aggregate score over 4 days shooting 600, 800, 900 and 1000 yards in 15 to 20 shot strings.