Experience is a BIG teacher however, only in powders pretty close to the "ideal" burn rate for that particular cartridge.
The best way to answer many questions is with examples: Example#1: Varget is in the "middle burn rate" of a the "chart". However, if you tried to use it in a .221 Fireball with 40gr bullet it would be on the "slow-side".. Conversely, if you used Varget in a .260A.I. with 140 gr bullets, it would be on the "fast-side".. The burn rate has not changed, however, the USE of it determines whether it might be too fast or too slow. Example#2: If you took a .300 WSM shooting 230 gr Hybrids for F-Open, you could use H4350, a powder in the slow lane, BUT on the faster side of the slow lane. H4350 will work and may work well, however, you would be much better served with either H4831SC or something like VV N165. The H4350 might give you exceptional accuracy but you would build pressure before you reached the upper limits of velocity, where H4831SC or N165 could get you there, sans the pressure. Additionally, if you run "faster" powders for your application, premature barrel wear can and usually does set in. Example#3: Take a .260A.I. using 130 grain bullets. You could run H1000 and probably get some decent accuracy. However, H1000 is a VERY slow powder and you would be better served with H4350. You PROBABLY could not get enough H1000 in the case to bring the pressures up to a point where you would get the 3000 F.P.S. you would be looking for. So in this instance, H1000 is too slow. On the other hand, a .300 R.U.M. shooting 230 grain pills would be better served with RL-33 or Retumbo rather than H1000. The H1000 would most certainly work, however, it definitely would be on the fast side of the powders needed to make that cartridge work best, not just work.. I hope this helps..