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25-06 Best bullet/powder for deer

You never mentioned how far you plan on shooting
Less than 300 yards: 117 Sierra Pro Hunter or 100 Partition
Over 300: Barnes 100 TTSX, 100 Swift Scirocco, 110 Nosler Accubond.

I am a biologist and shoot deer for health check surveys. I have shot 71 deer with my 25-06 and 257 Weatherby in the last 4 years. I have lost two deer: 1 with Gamekings and the other with 117 Hornady. The 100 Scirocco is the freaking hammer of Thor and next would be the Prohunter(just as good as partition but cheaper). The best powder I found was H-4831 SC.
 
"I have shot 71 deer with my 25-06 and 257 Weatherby in the last 4 years."

Now that's a mess of deer! Nice work.
 
I have never owned a 25-06, but I have killed 97 deer inthe last two years on damage permits and regular permits using a 6mm Remington and a 7 mag. The 25 would be a great caliber for deer eradication and I would have to go with the Hornady Interlock in 117 grain. My 6mm smokes them with the 100 grain Hndy at 3000 fps. As a matter of fact, number 97 was bang- flopped yesterday with a high-shoulder shot using that rifle.
 
Try 117gr sierra bt w/46.8 4350 imr. With a 24in. barrel, it should shoot .5inch groups or better. That`s 5-shot groups, and will nock the crap out of your animal. On deer out to 400yd. never had one go more two steps. Give a try. DB
 
Shot the old nosler 120 solid bases for years, but have now gone to the barnes 100gr tsx with great results. Always IMR4350.
 

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