- I run a ladder at the distance I'm shooting - pick a powder load from this.
 
- Then run a seating depth test with the given powder load to find the tightest group(s).
 
- Then I retest the powder/seating depth combination(s) to see if it's repeatable.  If so, that's my load for that rifle/barrel combination.  I will test around it to see if groups gets smaller or try other things like neck tension/primers...etc.
 
I'm still relatively new to LR shooting.  When I started 2 years ago, I started with a Dasher.  It could be (back then), I wasn't as proficient with my reloading, i was still learning proper bench manners, slow to get off shots....etc. ??   By the time I got the BRAI, I had more experience?   Is it the chambering or that the BRAI barrel sat on a different rifle/stock/action?  Or maybe it's the barrel on my Dasher?  Those aspects of shooting are beyond my comprehension.  Anyways, I found that the BRAI, over a given time period, shot consistently smaller (@600 yards) than my Dasher.  My limited 600 yard Dasher/BRAI experience mimics what 
@Tom has experienced at 1000 yards which Tom posted 
here.
At the few registered matches I've attended, shooters are still winning and setting records with Dashers (and BRAIs).
YMWV.