Gonzos First of all thanks for the heads up. What is involved in a bolt head change Will I require a new bolt? Never attempted to do anything like this I figured I'd post it here rather go into it with my gunsmith that way I know exactly what to ask.Yes a 22-250 shoots fine with a 1-12 twist. You will have the best luck with 40 to 55 grain bullets. You might be able to go heavier but don't count on it. Also remember that it will require a bolt head change.