Own a Sierra or Berger loading manual? I don't own the Berger book, and the Sierra is about 15yrs old; but... IF you start with the load parameters the premier accuracy bulletmakers recommend, IE use their recommended primer and their bullet, you will not have to sacrifice a good barrel trying to reinvent the wheel.
How much "testing" you gonna do?
Got a new barrel from a new barrelmaker?
Do you see where I'm going with this?
If you were shooting lead boolits, then you got minimal throat wear, but you're not... So you're gonna test several primers and vary your loads by fractions of a grain to see what delivers the opitimum. How many primers? What weights of how many powders? Gonna stay with one bullet?
If this is how you get your jollies; by all means... Yet, if you're shooting enhanced velocity loads, small diameter bullets, using slow burn rate powders and testing 5 or 10 rds (maybe more?) to determine which powder, weight, and primer; you're looking at hundreds of rounds fired.
Barrel life might be 1200-3000rds on average for decent precision. Optimum precision likely ends about 800rds with a 6mm or 6.5mm Whizzer. Shooting a large magnum? Lots less, if you got a brake and don't let your barrel cool between shots.
Why reinvent the wheel? If you've shot-out your throat getting that one ideal load, will the next barrel work as well?
Probably buy the Berger book and shoot their optimum load for the bullet you like. Try a couple and see which bullet your rifle likes. If you stay with the "accuracy load" you've eliminated a lot of variables. Because you are asking questions of this sort, probably best advice is to shoot the "accuracy load" until you can't improve. If the bulletmaker's accuracy/optimum load won't perform for you; it's either you or the rifle, presuming you can load good ammunition.