If you are developing loads for long range use then copy those that shoot at those ranges. One of the things that I see is fellows asking about load development who seem to have other rifle/shooting/ support system problems that need to be solved before they go off on their quest for a load. We have a lot of fellows out there messing with rifles that have not had their actions bedded and barrels floated, shooting barrels that may not be worth bothering with, and/or scope issues. I suggest that you look at why you are getting so much vertical. The reason that I asked about your equipment and distance is that things that matter at long range matter a lot less at short range. For instance, at long range uniformity of velocity is very important and shows up as vertical, while this is much less the case at short range. We cannot put wind flags out every few yards in the path of the flight of the bullet when doing load development at long range, and we can at short range, so long range shooters have to adapt to that reality in how they work up loads. You asked a very general question and blew me off when I asked for specifics, possibly not realizing that as with many things the best answer for a specific situation depends on those sorts of details. If you can come up with a load that has very low ES at a usable velocity working at short range, you will probably be able to tune it with seating depth to get what you need at long range. But if your are tuning for 1-200 yard benchrest, you will be working differently. ES is not nearly as important and you will be able to see what the wind is doing and actually look at groups rather than just vertical.