First of all, welcome to the land of the accurate shooter!
Your goal, as I understand it, is to be able to shoot a .66 moa group consistently at 300 yds. Your question(s) are what works and what doesn't to full-fill that goal. But the answer to that is that there is no simple answer. You'll need to shoot, quantify your results, modify, and repeat hundreds and even thousands of times.
Regarding your question about case volume vs weight, a simple test will provide some answers. Sort out your case outliers by weight and mark to identify. Load those as you do your selected cases. At the range, shoot some 5 or 10 shot groups with the selected cases, then shoot some groups with the outliers. Measure your groups for overall groups size and distance/angle from POA. Account for wind drift. Then back at home, measure case volume of all your spent brass just as it came out of the chamber and before any cleaning or die work. Note any trends and keep thorough records.
If you do this while using a chronograph, be certain it's accurate and record results.
In my limited experience, I've only been half seriously into this sport for about 5 years, the ability to shoot small groups come at a certain price.
To shoot MOA groups one only needs to purchase a good quality off the shelf weapon, ammo and scope and spend some time at the range.
To shoot sub 3/4 moa groups one needs do the above plus improve your marksmanship skills, go through the weapon system and correct any minor faults in the manufacture, assembly and set up of the system.
To shoot sub 1/2 moa groups one needs to do the above plus learn to hand load accurately, no small feat, and learn to read the wind accurately, an even bigger feat as well as purchase superior aftermarket parts such as competition grade barrels, stocks, scopes, mounts etc.
To shoot sub 1/4 moa groups you'll need start with a whole new and top quality custom built and expertly tuned weapon system, hand loading system, and improve your shooting and wind reading skills to expert levels. Join a club that hosts competitions in the area of your interest, seek out a mentor or two, and be prepared to spend many thousands of $$. It helps to have the eyesight and necessary skills too, both mental and physical. If you're a journeyman machinist, you already have a leg up on the quality parts.
I'm currently in the 1/2 moa group. Being retired and lacking a fat pension or rich Uncle, my budget is fixed. I will never own a custom built system, but I can still have fun with my cobbled together "Franken-Gun system shooting occasional groups in the two's, one's or even zero's when all the planets align.
