Long after I first received it from the gunsmith, I worked up a load with the 80.5s in a .223 Rem custom bolt (F-TR) rifle with a 26" barrel that was chambered with zero freebore. That particular rifle shot FGMM 77s extremely well, but I wanted to try a bullet with a little better BC that was more resistant to wind deflection. Due to the non-existent freebore and relatively short barrel (for F-TR, at least) I decided to use Hodgdon H322 powder to get them moving. Due to the fact that the base of the bullet was seated relatively deep below the neck/shoulder junction, the extremely small kernels of H322 were ideal.
Ordinarily, H322 would be considered much too fast for an 80.5 gr bullet. However, the load shoots extremely well and is not extraordinarily "hot" (i.e. ~2860 fps and brass life has been good). So using a smaller charge weight of a faster-than-normal powder was just the right recipe in this particular case. My recollection is that with the 80.5s seated at ~.020" off the lands, the loaded rounds were just barely short enough to feed from a 10-round AICS plastic mag. So it can definitely be done, although I will be the first to admit the practice is far from being "optimal".