The gun was built with a Bartlein 26" heavy palma and chambered for the 6 mm Grendle, looking to get 2800 fps at the muzzle. To mechanically actuate the bolt I added a straight pull bolt carrier and handle from Lantac USA (a British based company). The gun shot phenomenally well with sub-half minute groups at 200 yds and rang the bell consistently at 800 yards (could go no further due to scope limitations). While I did get my desired 2800 fps the cases had a sticking problem (could not unlock the bolt without knocking it back with a mallet handle) at that pressure and I had to drop back to 2760. Researching this problem led me to Target Shooter magazine where I learned the Brits, using a similar system, also had the sticking case problem when shooting hot loads. I should note here that in Britain, gas guns are outlawed and gasless ARs are common.
I had such a rifle in 223 Rem some years ago - actually, it was my first long-range number in the dawn of F-Class. I won a fair number of short and mid-range comps with it. It wouldn't today given current states of F/TR play!

To many Brits amazement, I shot it successfully in 800-1,000 yard matches with 80gn Sierra MKs. (When I say 'successfully', that means I could put 22 bullets into the frame and most into the standard NRA 1K 'black', but definitely not successfully in defeating people using cartridges like 6.5X55AI, nor a good 308 in terms of scores. This was a UK Southern Gun Company SSR-15 with extended manual handles on both sides built around a 24-inch Lilja match barrel with a modified Wylde chamber. The TS articles you refer to may have been mine.
This outfit would shoot genuine quarter-inch 5-round groups at 100 shot prone off a bipod and average somewhere in the 0.3-0.4" range - really quite astonishing. This was with fairly straightforward mild loads of VarGet or Re15 under the 80gn SMK in only basically prepped Winchester brass sized with an off the shelf - Hornady I think - FL sizer die and Redding Comp seater.
However, as Robert says, pressure and its effect on extraction/cycling are big issues. You didn't need pressure testing equipment to demonstrate how each 0.2gn step in charge weight increased chamber pressures and in turn the effort needed to get primary extraction. When I got QuickLOAD, I could see that calculated pressures of 55,000 psi were when things became (literally) sticky. I didn't have a chronograph then, but MVs were modest and the 80gn bullets were subsonic at 1,000 yards whispering silently through targets and confusing butts crews. As Robert also says, UK shooters lost access to semi-autos many years ago (with new legislation implemented in early 1989, the year after the Hungerford mass shooting using an AK47 type rifle), so I can't comment on how a built from scratch manual ('straight-pull') AR compares to the same rifle with gas operation in out and out precision terms.
With this type of AR being the dominant form in UK 'Tactical' and CSR (Civilian Service Rifle) competition, again as with Robert's experience, several people experimented with other cartridges, the Grendel and variations thereon being tried by some. Generally most people went back to 223 because of the manual operation / primary extraction issue as cartridges with cases with larger surface areas than the 6.8 Rem SPC tend to increase the pull needed on extraction and disrupt cycling. A friend, Dave Wylde, who is also a gunsmith and rifle builder and manual AR guru, CSR etc shooter, is now trying the 224 Valkyrie and reports very favourably on it, so this may at least partly replace 223 Rem over here in these rifles.